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KMID : 0604520140400040341
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Journal of the Society of Cosmetic Scientists of Korea
2014 Volume.40 No. 4 p.341 ~ p.347
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Melanogenesis Inhibition Effects of Nemopilema nomurai Hydrolized Extracts
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Lee Ha-Youn
Kim Young-Hoon
Um Sun-Young
Jung Uk-Sun
Jang Moon-Sik
Lee Nam-Ho
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Abstract
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This study was aimed to investigate skin whitening effects of Nomura's jellyfish (Nemopilema nomurai) hydrolyzed extracts (NHE). The extracts were prepared through the hydrolysis of N. nomurai using commercial proteolytic enzymes such as Protamex, Alcalase, Flavourzyme and Neutrase with optimum pHs (pH 5-8) at 55℃. Their whitening activities were examined from the inhibition of melanin synthesis using B16-F1 cell lines. Among the examined samples, Neutrase-treated extract (N-NHE) showed the most significant inhibition effect on melanin synthesis by 89.9% at a concentration of 100μg/mL. This sample decreased the expression of tyrosinase and TRP-1 (tyrosinase related protein-1) proteins as well. These results suggested the potential application of NHE as whitening ingredients in cosmetic preparation.
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KEYWORD
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Nemopilema nomurai, melanin synthesis inhibition, hydrolized extract, Neutrase, tyrosinase
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